I am recieving several of these log errors when I do a mailq.
How can I prevent that from coming into the queue?

2F38DEC1D2 3459 Mon Sep 18 03:33:53 MAILER-DAEMON
(connect to brmail1.brassring.com[66.77.22.180]: Connection
refused)
cbrown@1-jobs.com

20A3CEC0DF 834 Tue Sep 19 12:54:54 email@test.com
(connect to test.com[208.48.34.132]: Connection
timed out)
dfddfdt@test.com

Also I am recieving connection refused.

thanks